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In simbiology, getting error - "Matrix is close to singular or badly scaled. Results may be inaccurate. RCOND = 2.971666e-16"

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I am using simbiology for pharmacokinetics modelling. When i tried to use the non-mixed effect model using isqnonlin estimation method for fitting the data (in a two compartmental infusion model). I got the following error during fitting,
"Matrix is close to singular or badly scaled. Results may be inaccurate. RCOND = 2.971666e-16"
I came across similar question being asked in context of other fields of MALTAB.
But for Simbiology, if this error occurs, how to tackle it?
  2 comentarios
Sulaymon Eshkabilov
Sulaymon Eshkabilov el 17 de Jun. de 2019
Could you please be a bit more explicit and post some more details of your problem content?
Praveen Kumar M
Praveen Kumar M el 17 de Jun. de 2019
Thanks. Sorry for not being explicit. I had a pharmacokientics data of 50 patients which i tried to fit in two compartment model (drug administration type is infusion) using non-mixed effect model using isqnonlin estimation method. The error model which I kept was constant.
With this setting, I got a error that "Matrix is close to singular or badly scaled. Results may be inaccurate. RCOND = 2.971666e-16"
But I have now found the tentative solution for this. If I change the error model to either proportional, combined or exponential, the error has gone. Now i am getting the estimated parameter values.
Regards.

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