How do I disable a pushbutton while GUI is busy?

So, I have created a GUI with a pushbutton.
Since the code takes a little bit to finish, I want to disable the pushbutton while GUI is busy running that piece of code, and when it finishes I want to enable it again.
Is it possible?
Sorry for my bad English!
Thanks!

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el 6 de Mzo. de 2013

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