how to run tiff images?

how to run tiff images through matlab. i am getting this error while executing. my image size is more than 500 MB.

Error using rtifc

Maximum variable size allowed by the program is exceeded.

Error in readtif (line 48)

[X, map, details] = rtifc(args);

Error in imread (line 415)

[X, map] = feval(fmt_s.read, filename, extraArgs{:});

Error in tiff (line 1)

x = imread('test_046.tif', 'tif');