The Simulink platform supports co-simulation between components. In Simulink, co-simulation is between components with local solvers or involving simulation tools. For example, co-simulation can be an S-function implemented as a co-simulation gateway between Simulink and third-party tools or custom code, or an FMU in co-simulation mode imported to Simulink.
Use numerical compensation to mitigate numeric inaccuracies introduced by co-simulation signal delays.
Take advantage of the multiple cores in your system for co-simulation.
Export a Simulink model for use in a third-party environment.