- Check the Model for any presence of the Algebraic Loop in the model, you can use Diagnostics pane of the Model Configuration Parameters and set the Algebraic Loop parameter as "error", to show error if any Algebraic Loop is detected in the model.
- If your model generates the data which is of variable size, it is better to preallocate their size with the maximum limit such that computation would not be spent on resizing these variables.
- Try to use MATLAB Profiler or Simulink Profiler to find the bottlenecks present in the system and try to resolve them.
- Also try to plot the Simulation data in steps or in certain intervals such that MATLAB does not get overloaded with huge data.
- You can also try to increase the memory limit as MATLAB can get freezed due to lack of memory present for its operations.
- https://www.mathworks.com/help/simulink/ug/identify-algebraic-loops-in-your-model.html
- https://www.mathworks.com/help/simulink/slref/simulinkprofiler.html
- https://www.mathworks.com/help/simulink/slref/introduction-to-profiling-models.html
- https://www.mathworks.com/help/matlab/matlab_prog/resolving-out-of-memory-errors.html