APD 90 computation from a given action potential function

How can i compute the Apd 90 , the value at 90% of repolarization of action potential , for a given action potential

Answer 1

[Atharva]

Hey Viola,

To compute the APD90 (Action Potential Duration at 90% repolarization), you need the time series data representing the voltage during an action potential. Here's a general approach to calculate APD90:

1. Obtain the voltage values during the action potential at regular intervals (e.g., in milliseconds). You should have a series of voltage values that represent the entire duration of the action potential.
2. Identify the peak of the action potential. This is typically the highest voltage value reached during the depolarization phase.
3. Measure the voltage value at 90% repolarization. Repolarization is the phase when the voltage returns to its resting state or near-resting state. Start from the peak voltage and track the voltage values until you reach 90% of the repolarization level. This can be done by comparing each voltage value with the resting voltage level and determining when it reaches 90% of the difference between the peak and resting voltage.
4. Note the time at which you reach the voltage value determined in the previous step. This represents the APD90, the time it takes for the action potential to reach 90% repolarization.

Keep in mind that this is a general approach, and the specific methodology may vary depending on the experimental setup or the model you are working with.