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Equilibrate during parameter estimation

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Anu
Anu el 23 de Mayo de 2023
Comentada: Anu el 23 de Mayo de 2023
I have a reaction network model built using simbiology. This includes reactions for synthesis and degradation of various species. So, generally I run steadystate and update the model state before running any simulations. Now, I would like to estimate some of the parameters in the model using sbiofit. My questions is whether sbiofit equilibrates model state for each parameter sample during fitting?
Thanks and regards.

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Jeremy Huard
Jeremy Huard el 23 de Mayo de 2023
Hi @Anu,
running sbiosteadystate before each simulation in a fit is not supported.
That said, I see two options:
  1. If your case is simple enough, you might be able to express the species concentrations at time=0 as a function of parameters: e.g. receptor = ksyn/kdeg. I understand it might not be feasible though.
  2. You could shift the times in your data to fit by an offset large enough to reach steady state before the first dose is applied. To shift the time vector, you can add a derived column to the dataset in Model Analyzer and define it as the independent variable. For example:
Best regards,
Jérémy
  4 comentarios
Jeremy Huard
Jeremy Huard el 23 de Mayo de 2023
@Anu, I was assuming that the steady state would depend on the parameters you try to estimate. Can you please confirm?
If not, the solution would be simpler. Namely, you could run a steady state program, save the result in a variant, and then apply this variant in your fit program.
It would help if you could clarify that point.
Thanks!
Anu
Anu el 23 de Mayo de 2023
@Jeremy: Yes, the steadystate depends on the parameters that I am trying to estimate.
Thanks!

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