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Simbiology program code gave different results from my custom code

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Hello team,
I am working on a population pharmacokinetics (PK) project, so I am using sbiofitmixed() to solve the model.
However, I found that the fit program code directly exported from Simbiology Model Analyzer gave me different results from my custom code. Although I have all the settings set as the same, I have a problem with the parameter estimation on ka_Central.
My Simbiology Model Analyzer code can estimate this parameter with high confidence, but my custom code cannot.
I tried debugging but could not find where the problem came from.
Please find the code in the attachment file.
Thank you very much.

Respuesta aceptada

Jeremy Huard
Jeremy Huard el 25 de Mayo de 2023
the issue comes from the dose template. In the first version your taget is Drug_Central (corresponding to IV bolus) whereas in the second the tdrug target is Dose_Central (corresponding to EV).
Since no absoprtion takes place in the first version, ka cannot be estimated.
If you change the drug target to Dose_Central, you will be able to estimate ka.
  1 comentario
Jesse Chao
Jesse Chao el 26 de Mayo de 2023
Hello Jérémy,
What a naive mistake from me. Thank you for your precious time to point it out.
Hope you have a nice day Jesse

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Jeremy Huard
Jeremy Huard el 25 de Mayo de 2023
this is difficult to debug without the actual model and data.
Would you be able to share them?
That said, I noticed a discrepancy in the initial values of both versions because of the order of estimated parameters (ka, Central, CL) instead of (ka, CL, Central).

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