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Simulation error in Simbiology

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Day el 29 de Mayo de 2023
Respondida: Jeremy Huard el 31 de Mayo de 2023
I checked the tumor growth model in the library of Simbiology. I noticed if I increase the drug concentration to very high values, the proliferating tumor mass, x1, never goes to zero or negative values. This happens also when I increase the simulation time or the number of RepeatCount . Would you please tell me what part of the model prevents that from happening?
I developed the same model for different type of drug. I have the same solver settings as in the original model found in the library. I checked carefully that everything is the same as much as possible. However, the tumor species, x1, goes to minus values if I increase the simulation time, which doesn't happen with the original model. Therefore, I receive error message and I can't perform the simulation. Does it make sense that it goes to negative values? because for long time, tumor mass is kept taking out in a rate defined by the killing rate and at some point the species will go to negative value. Could you please help in correcting me and clarifying the situation?

Respuestas (1)

Jeremy Huard
Jeremy Huard el 31 de Mayo de 2023
Hi @Day,
can you please share the project file you are using?
Assuming you are using the tumor_growth_fitPKPD_completed.sbproj project shipped with R2023a, I tried to increase the dose amount to 100mg for example and tumor weight goes down to 0 after 35 days. Likewise if I increase the RepeatCount property.
It does not become negative though and should not. If you see negative values on your side, I would recommend to check the solver tolerances and possibly the model equations.
Best regards,

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