How to compute NCA in case of drug infusion in Simbiology? There are options for bolus doses but is there a option to compute for drug infusion regimen?
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Praveen Kumar M on 7 Jun 2019
Non Compartmental Analysis (NCA) is easily performed in Simbiology for drug bolus. With the data imported and selected, selection of Define Plot then Open followed by NCA will directly give the the results of all standard NCA parameters. But suppose my drug is given by infusion, and I want to compute NCA, how to do it?
To be more specific, there is no option to to add rate of infusion data in Simbiology during computation of NCA.
I have attached a screenshot for better understanding. In the screenshot attached, as you can see there is no option for adding rate of infusion. In this case, is the drug infusion, I suppose is to be considered as drug bolus and then I have to compute NCA. Is this not wrong?
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