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Hello Matlab Community, I have a one-compartment pharmacokinetic model with the following parameters: Ka=0.8 (1/Hour), CL=26 (Liters/Hour), Vd=947 (Liters). I am administering is 10mg every 24-hours 14-days = 336-hours. What I would like to do is to add in a trough plasma concentration at 14-days of 40ng/mL. What I would like to see if Simbiology can do is to estimate the Clearance Rate (CL) alone by keeping the Ka and Vd fixed at time=336hours and concentration=40ng/mL. I can do this manually, by adjusting the Clearance Rate parameter, but I was looking to see if this may be automated to fit the data-point or concentration at time point 336hours of 40ng/mL. Thus, time=336, concentration=40ng/mL. Thanks for your help.