How can I simulate a 1-compartment PK and Indirect Turnover PD Model within the Simbiology Graphical Interface?

Hi, Do you have an graphical Simbiology example that would allow me to simulate a PK/PD Model in Simbiology model for a 1-compartment PK Model with a Indirect PD Turnover with the following equation: dR(t)/dt = kin*(Baseline-(Emax*C(t)^gamma)/(EC50^n+C(t)^gamma)) - kout*R(t) where kin=kout*R0, based on steady-state solution R'(t)=0=kin-kout*R(0) for C(0)=0.

This PD model is a slight modification from the current Matlab code: https://www.mathworks.com/matlabcentral/fileexchange/43521-preclinical-pkpd-modeling/content/MatlabShared_20140915/PD_turnover_stimOfProd_ode.m

I want to just do this using a graphical interface in Simbiology.

Thank you for your help.

Answer 1

[Arthur Goldsipe]

Here are course materials that include a warfarin model.

Here are two other example PKPD models:

• SimBiology model for PK/PD of antibacterial drugs
• SimBiology model for PK/PD of anticancer drugs

You might also find the following links helpful:

• File Exchange search for SimBiology and PKPD
• SimBiology PK resources

Answer 2

[Andy]

Thanks Arthur for the reply and the website links.

This was very helpful.