Transit Compartments with Simbiology

Do you have a good example in Simbiology for me modify the built-in PK models that would create 3 transit compartments prior to absorption.

Basically, I would like to create a one-compartmental PK model with 3 transit compartments and then the standard Ka parameter with first order dosing. I then want to do the same for a 2-compartmental PK model with 3 transit compartments prior to absorption.

Example 1: V, CL, Ka, MTT and Example 2: Vc, CL, Q, Vp, MTT

I attempted to use the gPKPDSim package and thought to use the standard Simbiology interface instead.

Andy

Answer 1

[Arthur Goldsipe]

Have you seen the documentation example Estimate Pharmacokinetic Parameters Using SimBiology Desktop? It walks you through selecting a PK model from the built-in library within SimBiology. You should see that there are several options for 3-compartment models. See if any of those are a good starting point for you.

Answer 2

[Andy]

Hi Arthur, I opened the 3-compartment PK model and will modify the contents.

I will take good look at this and get back to you.

Thanks, Andy

Answer 3

[Andy]

Arthur, I saw the concept from the 3-compartment model and was able to create the 3 transit compartments by modifying a two-compartment model in approximately 1-hour. So, thank God, it worked.

Thanks.