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Sietse Braakman


Last seen: 2 días ago

MathWorks

33 total contributions since 2017

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Answered
condition in which one compartment does not affect the mass balance
Hi Kazutaka, In the example you are following along with (https://www.mathworks.com/help/simbio/ug/model-views.html), the PK pa...

alrededor de 1 mes ago | 1

| accepted

Answered
Dimensional analysis fail for reaction on simbiology
Hi Chi Chun, The dimensional analysis ensures that the units in your model are consistent. However, this requires you to specif...

alrededor de 1 mes ago | 1

Answered
Export model to workspace - missing dose
Hi Jacopo, When you export the model to the MATLAB workspace, by right clickin on the model in SimBiology and selecting 'Export...

alrededor de 2 meses ago | 0

Answered
Simbiology stimulation reactions in custom PDPK models
Hi Daniel, It sounds like you're mostly there. For each reaction, you can define the stoichiometry (e.g. null -> x) as well as ...

alrededor de 2 meses ago | 1

| accepted

Answered
In Simbiology, is it possible to run stochastic simulations with Gillespie’s algorithm?
Hi Hassan, You can do this by choosing a stochastic solver. In the user interface, this can be done by going to the 'Simulatio...

2 meses ago | 1

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Answered
How to change dose intervals or activate/deactivate dose during simulations in SimBiology?
Hi Hanwen, If I understand you correctly, you could follow one of two routes: use three separate Repeat Doses. One for day 1,...

3 meses ago | 1

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Answered
Question about Simbiology Model Publication
Hi Brett, There are multiple ways to do this: You can share the .sbproj file - this is the easiest way for others to use your ...

3 meses ago | 0

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Answered
Unable to add an event block to a reaction rate in SimBiology
Hi Jacopo, The parameter you are adding the event function to, ke, is currently "reaction-scoped". If you change the scope of y...

4 meses ago | 2

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Answered
using MaximumWallClock in a loop
I am not sure I understand what you mean by "EndTime". There are two things we need to separate here: the wall clock time (the a...

5 meses ago | 0

Answered
using MaximumWallClock in a loop
There is no built-in flag but you could exclude any simulation for which the final time step does not equal your stop-time. Let ...

5 meses ago | 2

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Answered
Problem with Fit Data in SimBiology
Hi Valentina, Looking at your description of the problem and the files you attached I have a few thoughts on what could be happ...

5 meses ago | 0

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Answered
How to do model fitting to sum up two concentration in simbiology
You can create a species ACRG and use a repeated assignment rule to assign the sum of ACRG1 and ACRG2 to ACRG. The repeated assi...

5 meses ago | 1

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Answered
Simulation stop criteria for simfunctions and sbiofit
Hi Abed, Interesting questions - Yes, most settings are inherited from the active configset. The most notable exceptions are ...

9 meses ago | 1

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Answered
How do I complete a Visual Predictive Check in Simbiology PopPK sbionlmefitsa
Hi Andy, Thank you for the feedback. To support my suggested approach with a more concrete example, we have written a function ...

10 meses ago | 0

Answered
Mass balance issues with PBPK model in Simbiology
Hi Andrew, This might be an integration imprecision in the solver due to tolerances that are not strict enough. Have you trie...

10 meses ago | 0

Answered
Is there a listing of functions (such as 'trapz') to use in SimBiology explorer?
Hi Andrew, You could use the following: Cmax: max(Central.Drug_Central) Tmax: time(Central.Drug_Central == max(Central.Drug...

10 meses ago | 0

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Answered
How do I complete a Visual Predictive Check in Simbiology PopPK sbionlmefitsa
Hi Andy, Please excuse the late reply. Have you looked into using sbiosampleparameters? This function allows you to sample your...

10 meses ago | 0

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Answered
Specifying different variants for different groups in 'sbiofit'
Hi Abed, We get this question quite regularly - the best way to do this currently is by using dosing. What you have to do: In ...

alrededor de 1 año ago | 0

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Answered
How to change model parameter value in exported simbiology model?
Hi Rajeev, To clarify - there are two ways I can interpret your question primarily because 'exporting' a SimBiology model can m...

alrededor de 1 año ago | 1

| accepted

Answered
Log likelihood is initially high in FOCE but as the iteration proceeds to greater than 3500 the log likelihood reduces and finally ends with error that maximum iteration has been achieved.
Dear Praveen, Generally, parameter estimation is a complicated topic that inherently has a lot of ambiguity. This makes it dif...

alrededor de 1 año ago | 1

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Answered
Does SimBiology provide a PK model with an infusion turned on and off during simulation?
You can dose your model by adding a dose object (e.g. a Repeat Dose) to the species you want to dose. In the image below, the sp...

alrededor de 1 año ago | 0

Answered
Data Extraction from SimBiology Simulations
It looks like you are on Mac OS - the export to Excel uses the function xlswrite, which unfortunately only works on Windows. h...

alrededor de 1 año ago | 0

Answered
Data Extraction from SimBiology Simulations
Hi Andrew, Assuming you are using the SimBiology app, you can do this by right-clicking on the simulation plot and selecting 'E...

alrededor de 1 año ago | 1

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Answered
TissuePartition Function Inclusion into SimBiology PBPK
Hi Andrew, Are you trying to pull out the values of the partition coefficients or the model equations? In general, SimBiology ...

alrededor de 1 año ago | 1

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Answered
Issues fitting ka parameter
Hi Brett, There are three ways you can approach this: by assuming that the dose is reduced by a factor F, such as Peter sugges...

más de 1 año ago | 0

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Answered
reproducing sensitivities from MATLAB GUI
A typical use case for this question is when calculating a sensitivity on species C, where species C is a linear combination of ...

más de 1 año ago | 0

Answered
Is there an object associated with simulate task in the simbiology desktop that contains the name of the task?
Hi Jim, These are good questions. Currently, there is no way to access the task name from the desktop, or from MATLAB. One so...

más de 1 año ago | 0

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Answered
How do I calculate a confidence interval for a simulation from a PK model?
Since R2017b, SimBiology has two functions to calculate confidence intervals. At the time this question was asked, these functio...

más de 1 año ago | 1

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Answered
How to assign to a SimBiology model a parameter value (known and constant) changing for each data in the dataset for a non-linear mixed effect estimation?
Hi Anne, As of 2018b, there is no easier way to achieve this, other than the method described by Arthur above. We are aware tha...

más de 1 año ago | 0

Answered
Infinite StandardError with sbiofit
Fitting problems like the one Hussein describes tend to be difficult to troubleshoot online, especially when the model/data cann...

más de 1 año ago | 0

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